| Title | Address | Description |
|---|---|---|
LMU | GESCHWISTER SCHOLL PLATZ 1, 80539 München, |
|
Fundació Clínic per a la Recerca Biomèdica | Carrer del Rosselló, 149, 08036 Barcelona, Spanien |
|
Helmholtz-Zentrum für Infektionsforschung GmbH (HZI) | Ingolstädter Landstraße 1, 85764 Oberschleißheim, Deutschland |
|
Helmholtz ZentrumfürInfektionsforschung GmbH | Inhoffenstraße 7, 38124 Braunschweig, Deutschland |  |
Medizinische Hochschule Hannover | Carl-Neuberg-Straße 1, 30625 Hannover, Deutschland |
|
NIMR-Mbeya Medical Research Center | Hospital Hill Rd, Mbeya, Tansania |
|
Technische Universität München | Arcisstraße 21, 80333 München, Deutschland |
|
UNIVERSITY COLLEGE LONDON (UCL) | GOWER STREET, WC1E 6BT London |
|
Klinikum Rechts der Isar der Technischen Universität München | Hörsaal A, Klinikum rechts der Isar, Ismaninger Str. 22, 81675 München, Deutschland |
|
University Medical Center Hamburg-Eppendorf, I. Department of Internal Medicine | Martinistraße 52, 20251 Hamburg, Deutschland |
|
Azienda Ospedaliero- Universitaria di Parma | Str. dell'Università, 12, 43121 Parma PR, Italien |  |
Universität Leipzig | Ritterstraße 26, 04109 Leipzig, Deutschland |
|
Barts Health NHS Trust | Co-operative Bank Plc, 9 Prescot St, Whitechapel, London E1 8AZ, Vereinigtes Königreich |
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Royal Free London NHS Foundation Trust | Pond St, Hampstead, London NW3 2QG, Vereinigtes Königreich | |
ARTTIC Innovation GmbH | Oskar-von-Miller-Ring 29, 80333 München, Germany |
|
MONIPOL - Clinical Research | Roncallistraße 39, 53123 Bonn, Germany |
|
Helmholtz-Zentrum für Infektionsforschung GmbH (HZI)
General Information
The Helmholtz Centre for Infection Research (HZI) in Braunschweig is a publicly funded research centre with more than 900 employees and an annual budget of approximately 70 million Euros as well as external funds of approximately 16 million Euros from national and international support programmes and industry. The focus of its activities lies in the field of infection. The mission of the HZI is to rise to the societal challenges of infectious diseases by investigating their fundamental mechanisms of pathogenesis, with the aim of deriving innovative approaches for their prevention, diagnosis and therapy. The HZI is also a member of the German Centre for Infection Research (35 research institutions located at seven sites), with the managing office located at the HZI campus.
The scientific activities in the Department of Vaccinology and Applied Microbiology, headed by Prof. Carlos A. Guzmán are dedicated to:
- elucidating the mechanisms of host response to infection and vaccination,
- developing new adjuvants and antigen delivery systems, and
- developing and validating vaccines against specific infectious diseases.
This encompasses:
establishing adjuvants and nanocarrier-based delivery systems,
- developing vaccines against specific pathogens (eg. hepatitis B and C viruses, influenza virus, Trypanosoma cruzi),
- generating advanced immune monitoring approaches to assess innate and adaptive immune responses following vaccination in preclinical models and humans,
- assessing responses to vaccines in humans, and
- identifying genotypic and early phenotypic immune signatures predicting successful vaccination.
Helmholtz-Zentrum für Infektionsforschung GmbH
Inhoffenstr. 7
38124 Braunschweig
Germany
Role in TherVacB
Prof. Guzmán and his group at the HZI have studied and developed c-di-AMP as a potent novel adjuvant and patented its use for therapeutic and prophylactic vaccination. Non-GLP proof-of-principle studies demonstrated that c-di-AMP was able to improve both the humoral and the cellular immune responses to disease-related antigens of Streptococcus pyogenes, HBV, HCV, influenza virus, and Trypanosoma cruzi upon parenteral or mucosal vaccination. The HZI will not only contribute c-di-AMP to the TherVacB project, it will also contribute its expertise to assist in preparing the clinical trial dossiers, obtaining regulatory approval and developing the data management plan, as well as support data collection and management during the clinical trial.
Project Staff
Carlos Alberto Guzmán
Head, Department of Vaccinology and Applied Microbiology
Scientific Management,
Vaccinology and Immunology
Thomas Ebensen
Senior Scientist
Scientific Management,
Vaccinology and Immunology
Blair Prochnow
Project Manager
Project Management